Ambrose married Judith Ann Anderson in 1725 in Louisa, Louisa, Virginia, United States. Judith (daughter of Thomas Anderson and Agnes Gannaway) was born on 11 Jun 1704 in Hanover Parish, King George, VA, USA; died in Aug 1758 in Rowan, Chatham, North Carolina, United States. [Group Sheet] [Family Chart]

1. Christopher Buckner Smith was born about 1730 in Virginia, British Colonial America; died in Dec 1804 in Greenville, Spartanburg, South Carolina, United States.
2. Col. John Christopher Smith was born in 1720 in Hanover, Virginia, United States; died in 1793 in Springfield Plantation, Johnston, North Carolina, United States.
3. John Purtis Smith was born in 1725 in Wales; died about 1793 in Tennessee, United States.
4. Henry Smith was born in 1727 in Ulster, Northern Ireland, United Kingdom; died on 10 Mar 1792 in York, South Carolina, United States.
5. Nathan Nicholas Smith was born on 18 Jun 1730 in Moore, North Carolina, United States; died in 1811 in Franklin, Georgia, United States.
6. George Smith was born in 1732 in North Carolina, British Colonial America; died in 1800 in Edgecombe, Pender, North Carolina, United States.
7. Susannah Smith was born about 1734 in Isle of Wythe, Virginia; died before 1833.
8. Zachariah Smith was born on 19 Aug 1734 in Louisa Court House, Louisa, Virginia, British Colonial America; died on 28 Nov 1831 in Smith's Creek, Wilkinson, Mississippi, United States.
9. William Smith was born in 1738 in Hanover, Louisa, Virginia, United States; died in 1782 in Bladen, North Carolina, United States.
10. Francis Marion Smith was born in 1740 in Staffordshire, England, United Kingdom; died in Dec 1790 in Charlotte, Mecklenburg, North Carolina, United States; was buried in Dec 1790 in Charlotte, Mecklenburg, North Carolina, United States.
11. Judith Smith was born in 1740 in New Kent, Virginia, British Colonial America; died in 1800 in Laurens, South Carolina, United States.
12. Ambrose Joshua Smith was born about 1742 in Hanover, Virginia.

Christopher married Catherine Snelson on 9 Feb 1730 in Louisa, Louisa, Virginia, British Colonial America. Catherine was born in unknown. [Group Sheet] [Family Chart]