Isaac married Mehitable Millett about 1665 in Dorchester, Suffolk, Massachusetts Bay, British Colonial America. Mehitable was born on 14 Mar 1642 in Dorchester, Suffolk, Massachusetts, British America; was christened on 20 Mar 1642 in Dorchester, Suffolk, Massachusetts, United States; died on 28 Sep 1699 in Gloucester, Essex, Massachusetts Bay, British Colonial America; was buried in 1699 in Gloucester, Essex, Massachusetts Bay, British Colonial America. [Group Sheet] [Family Chart]

Isaac married Mary Prince on 16 Dec 1702 in Gloucester, Essex, Massachusetts Bay, British Colonial America. Mary was born on 19 Jul 1658 in Gloucester, Essex, Massachusetts Bay, British Colonial America; died on 3 Mar 1723 in Gloucester, Essex, Massachusetts, United States; was buried in 1723. [Group Sheet] [Family Chart]